The amine fluoride/stannous fluoride combination was developed by GABA in the 1980s. Its distinctive anti-bacterial and plaque and inflammation-inhibiting properties have already been investigated in more than 100 scientific studies. The active ingredient combination of amine fluoride and stannous fluoride is used in all meridol products.
For decades the inorganic stannous fluoride has been renowned for its marked antibacterial and thus plaque-inhibiting effect. The antibacterial properties of the two fluorides are synergetically strengthened in this combination.
When the amine fluoride/stannous fluoride complex reaches the oral cavity, the surface activity of amine fluoride ensures that it is rapidly distributed and transported to the surface of the teeth.
In order to become active, the stannous ions must then be rapidly released from the amine fluoride "cage". This occurs by means of exchange with calcium ions from the saliva. Stannous ions are thus released on the surface of the teeth, and can exert their antibacterial effects on plaque by disrupting their metabolism.